Casting the Net Wider: Network Approaches to Artefact Variation in Post-Roman Europe

Casting a wider net: whole-cell assays to capture varied and biased signaling.

The observation of complex receptor behaviors has shown how ligands can have multiple efficacies and can also differentially stimulate certain cellular signaling pathways over others (i.e., biased signaling). Conventional pharmacological assays (usually proximal to the receptor) will detect ligands that produce the signal defined by the assay (i.e., Ca²⁺, cAMP, and others) but otherwise may mis...

Molecular Pharmacology: Perspective Casting a Wider Net: Whole Cell Assays to Capture Varied and Biased Signaling

Casting a Wider Net: The Quest for Better Guidance on Seafood Consumption

Fish is the primary dietary source of omega-3 long-chain polyunsaturated fatty acids, which are necessary for healthy prenatal development and linked to reducing cardiovascular disease risk. The type and quantity of seafood that individuals choose to eat can impact both their health and the long-term sustainability of the world’s fisheries. An interdisciplinary team of researchers wants consume...

Casting a Wider Safety Net: The Promise of Electronic Safety Event Detection Systems.

Casting the autophagy net

C ells can degrade cytoplasmic components by capturing them inside a double-membraned vesicle called the autophagosome that then delivers them to lysosomes to be broken down and recycled. This process, known as autophagy, occurs at basal levels in all cells, and is upregulated in response to starvation or other stresses as a cell survival mechanism. But autophagy is a double-edged sword that ca...